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Manufacturing system for liquid preparations

Bottle filling lines (for oral and external liquid preparations) were newly established in 2004 and filling operations are performed within a laminar flow booth. A wide range of formulations from ordinary types of syrups through to liquid preparations with high viscosity, liquid dosage forms with weak antiseptic power are manufactured.

Manufacturing process of performable contract manufacturing for liquid preparations
Liquids filling machinePreparation tank for liquids Note:Click here to enlarge the image.
List of facilities for manufacturing liquids (Pharmaceuticals building)
Process Name of facility or equipment Manufacturer & model Capacity & specifications
Liquids line (1) Solution preparation tank Nishida Doukousho Co., Ltd. 500 L with jacket: 85ºC
Rotary bottle washer Oogi Machinery Co., Ltd. SR-24 Capable of handling 100 mL vials, 20 vials/min
Filling machine Oogi Machinery Co., Ltd. Capable of handling 100 mL vials
Seamer Yoshimura Tekkosho E-3B-OCCM
Visual inspection Machine Oogi Machinery Co., Ltd.
Liquids line (2) Solution tank Daiei Inc. 100 L (Teflon coated)
Preparation tank Daiei Inc. 2000 L with jacket: 85ºC
Storage tank Daiei Inc. 2000 L
Bottle washer Nagata seisakusho Co., Ltd. NBR-6 Capable of handling 100 mL and 500 mL bottles, 40 bottles/min.,
WFI washing, air washing
Filling machine KT. MFG. Co., Ltd. 5FL-WT Capable of handling 100 and 500 mL bottles, 40 bottles/min., weight-filling method
Capper KT. MFG. Co., Ltd. 2C-TC Capable of handling 100 and 500 mL bottles, 40 bottles/min., torque-controlled method
Labeling and packaging Bottle labeler Sun-Tec Company,Ltd. ST-VRHP up to 1800 bottles/h
Cartoning machine Fuji Astec Co., Ltd. CMVA up to 1800 bottles/h
List of facilities for manufacturing tube preparations
Process Name of facility or equipment Manufacturer & model Capacity & specifications
Preparation of solution Solution tank Trytech Co.,Ltd. 100 L
HCl storage tank Trytech Co.,Ltd. 100 L
Preparation tank Trytech Co.,Ltd. 2000 L
Heat sterilizer for liquid Okawara Corporation. KLP-5 350 L/h maximum
Storage tank Trytech Co.,Ltd. 2000 L
Filling Tube feeder IWK Verpackungstechnik GmbH TZ102 160 tubes/min.
Tube filling and Seal printer IWK Verpackungstechnik GmbH TFS-80-2 Hopper capacity: 55 L, 160 tubes/min.
Tube inside inspection machine Pharmalead Engineering Co., Ltd. 180 tubes/min.
Weight checker Anritsu Corporation KW6003FP2C Maximum capacity: 60 g, Sensitivity: 0.05 g
Tube puncture & Seal inspection machine Pharmalead Engineering Co., Ltd. 170 tubes/min.
Packaging Cartoner (individual packaging) O-M, Ltd. 200 tubes/min.
Caser O-M, Ltd. 2 cases/min.
Tube filling
Note:Click here to enlarge the image.
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