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Spray dry manufacturing technology

In the building dedicated to spray dry manufacturing, 2 spray driers for manufacturing scale production are installed, where technology of achieving a drug-delivery system with drug/drug inclusion complexes and technology of making slightly soluble medicines soluble are applied for manufacturing scale production. In April 2007, a spray drier for pilot plant scale production was newly installed. Manufacture of investigational products and manufacture of drug products in small lots is also practicable.

Performable contract manufacturing processes of Spray dry (granulation) and mixing
* 2 spray driers for manufacturing scale production (Models CS-50 and ODA-27 made by Ohkawara Kakohki Co., Ltd.)
* 1 spray drier for pilot plant scale production (Model OC-20 made by Ohkawara Kakohki Co., Ltd.)
List of facilities for spray dry process and manufacture
Process Name of facility or equipment Manufacturer & model Capacity & specifications
Liquid preparation For manufacturing scale production Dispersion tank Daiwa Kakoki 1300 L tank
Storage tank Daiwa Kakoki 1300 L tank
Solution preparation tank Ohkawara Kakohki Co., Ltd. 200 L tank x 2 tanks
For pilot plant scale production Solution preparation tank KI Kakoki Co., Ltd. 500 L tank
Feeding tank KI Kakoki Co., Ltd. 250 L tank
Service tank - 50 L
SD washing water pump Nikunima-shinari 641-1S 70 L/min
SD pump Heishin Ltd. 60 kg/h x 2 pumps
Continuous vacuum degasser Ebara Corporation UDC1-SM 60 L/h
Spray dry For manufacturing scale production Spray drier Ohkawara Kakohki Co., Ltd. Model CS-50
Drum body diameter: 2.75 m
Height: 3 m for straight tube portion, 2.5 m for cone portion
Amount of moisture evaporation: 55.5 kg/h
Disk spray-parallel method
Water soluble solvents only
Ohkawara Kakohki Co., Ltd. Model ODA-27
For pilot plant scale production Spray drier Ohkawara Kakohki Co., Ltd. Model OC-20 Drum body diameter: 2 m
Height: 1.2 m for straight tube portion, 1.7 m for cone portion
Amount of moisture evaporation: 23 -42 kg/h
Disk spray-parallel method
Water soluble solvents only
Facility for water for manufacturing   RO membrane-ion exchange unit NGK Filtech, Ltd. 1.0 m3/h
Mixing & subdividing   Bohle container mixer Kotobuki Industries Co., Ltd. MC1200/PM1000 1200 L tank x 3 tanks
Circular oscillating sieve Tokuju Corporation TM-50 Output: 0.4 KW
Metallic foreign bodies eliminating apparatus Magnetec Japan Ltd. Grid type magnet 12000 gauss x 14 units
Automatic can weighing apparatus Osaka Godo Keiso 30 kg at maximum x 2 units
Spray drier for pilot plant scale production
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